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Vasoactive intestinal polypeptide stimulates cholecystokinin secretion in perfused rat duodenum
A Funakoshi1, I Nakano, K Miyazaki
1National Kyushu Cancer Center, Fukuoka, Japan.
The Tohoku Journal of Experimental Medicine
|January 1, 1989
Abstract:
We examined the effect of vasoactive intestinal polypeptide (VIP) on cholecystokinin (CCK) secretion from the isolated perfused rat duodenum. VIP stimulated CCK secretion mono-phasically in a concentration-dependent manner in concentrations ranging from 10(-9) to 10(-7) M, and 10(-7) M of VIP led to an increment of 82 +/- 25.8 fmole/3 min. The stimulatory effect of VIP on CCK was not inhibited by 10(-5) M atropine. These results suggest that VIP may directly stimulate CCK secretion from the duodenum and work as a non-cholinergic, peptidergic neurotransmitter.