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Updated: Mar 22, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Preoperative macular spectral-domain optical coherence tomography in patients considering advanced-technology
Betty R Klein1, Emma N Brown1, Richard S Casden1
1From the Western Connecticut Health Network (Klein, Casden), Danbury, Connecticut, and Mt. Holyoke College (Brown), South Hadley, Massachusetts, USA.
Purpose:
To evaluate spectral-domain optical coherence tomography (SD-OCT) as a strategy for identifying occult macular disease preoperatively in patients scheduled for cataract surgery with implantation of an advanced-technology intraocular lens (IOL).
Setting:
Private practice, Danbury, Connecticut, USA.
Design:
Retrospective consecutive case series.
Methods:
Macular SD-OCT scans were performed on all patients scheduled for cataract surgery and Restor multifocal or toric IOL implantation over a 6-month period. All scans were reviewed for abnormalities of the retina, retinal pigment epithelium, or vitreomacular interface. For subgroup analysis, the following health information was collected: age, sex, smoking history, hypertension, heart disease, hyperlipidemia or hypercholesterolemia, and diabetes.
Results:
Two hundred sixty-five consecutive scans from 149 patients were obtained. Macular pathology was found in 35 eyes (13.2%). The most common condition was age-related macular degeneration in 15 eyes (5.66%) followed by idiopathic epiretinal membrane in 11 eyes (4.15%). Ischemic atrophy from previously undiagnosed retinal vascular pathology was found in 5 eyes (1.89%) and edema in 3 eyes (1.13%). A subgroup analysis found a higher incidence of macular pathology in patients with a history of heart disease (30.6%, P < .001) or smoking (20.2%, P < .05), and in men (23.9%, P < .01). Media opacities precluded interpretation of 17 scans (6.42%).
Conclusion:
Preoperative macular SD-OCT scanning was effective in identifying patients at risk for compromised visual outcomes after advanced-technology IOL surgery.
Financial Disclosure:
None of the authors has a financial or proprietary interest in any material or method mentioned.
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