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Updated: Mar 22, 2026

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
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Published on: April 18, 2016

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CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and

Kanin Salao1, Lele Jiang1, Hui Li1

  • 1St Vincent's Centre for Applied Medical Research, St. Vincent's Hospital and University of New South Wales, Sydney, New South Wales 2010, Australia.

Biology Open
|April 27, 2016
PubMed
Summary

Intracellular chloride channel protein 1 (CLIC1) regulates dendritic cell (DC) function by controlling phagosomal pH. This finding suggests CLIC1 as a therapeutic target for reducing adaptive immune responses in autoimmune diseases.

Keywords:
AcidificationAntigen presentationCLIC1Dendritic cellsPhagosomeProteolysis

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