Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Influencing Heart Rate01:30

Factors Influencing Heart Rate

7.2K
The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
7.2K
Regulation of Heart Rates01:31

Regulation of Heart Rates

4.4K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
4.4K
Human Genetics01:28

Human Genetics

1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

106
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
106
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

3.2K
Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
3.2K
Correlation between ECG and Cardiac Cycle01:25

Correlation between ECG and Cardiac Cycle

14.5K
The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
14.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying Sociodemographic Community Variables and High School Characteristics Predictive of Subsequent College Alcohol Consumption: Integrating Self-Report, Census, and School Administrative Data.

Substance use & misuse·2026
Same author

Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.

Psychological medicine·2025
Same author

"General Addiction Liability" Revisited.

Clinical psychological science : a journal of the Association for Psychological Science·2025
Same author

Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.

medRxiv : the preprint server for health sciences·2025
Same author

Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design.

PloS one·2024
Same author

Maternal smoking during pregnancy is associated with DNA methylation in early adolescence: A sibling comparison design.

Developmental psychology·2024

Related Experiment Video

Updated: Mar 22, 2026

Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions
08:12

Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions

Published on: June 5, 2019

20.7K

Genetic influences on heart rate variability.

Simon Golosheykin1, Julia D Grant1, Olga V Novak1

  • 1Washington University School of Medicine, St. Louis, MO, USA.

International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology
|April 27, 2016
PubMed
Summary

Heart rate variability (HRV) and resting heart rate (HR) are highly heritable in young adults. Genetic factors significantly influence HRV across different measurement domains and show overlap with HR, with some sex-specific genetic influences observed.

Keywords:
Autonomic balanceGeneticsHeart rate variabilityHeritabilityTwins

More Related Videos

Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology
05:48

Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology

Published on: September 21, 2018

10.7K
Author Spotlight: Advancing the Study of Brain-Heart Interplay with a Comprehensive EEGLAB Plugin for Multimodal Signal Analysis
08:22

Author Spotlight: Advancing the Study of Brain-Heart Interplay with a Comprehensive EEGLAB Plugin for Multimodal Signal Analysis

Published on: April 26, 2024

3.4K

Related Experiment Videos

Last Updated: Mar 22, 2026

Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions
08:12

Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions

Published on: June 5, 2019

20.7K
Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology
05:48

Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology

Published on: September 21, 2018

10.7K
Author Spotlight: Advancing the Study of Brain-Heart Interplay with a Comprehensive EEGLAB Plugin for Multimodal Signal Analysis
08:22

Author Spotlight: Advancing the Study of Brain-Heart Interplay with a Comprehensive EEGLAB Plugin for Multimodal Signal Analysis

Published on: April 26, 2024

3.4K

Area of Science:

  • Genetics
  • Autonomic Nervous System
  • Cardiovascular Physiology

Background:

  • Heart rate variability (HRV) reflects autonomic nervous system (ANS) function and is linked to health outcomes.
  • Previous research indicates significant heritability of HRV measures.
  • Individual differences in HRV are associated with emotion regulation, personality, psychopathology, cardiovascular health, and mortality.

Purpose of the Study:

  • Investigate sex differences in the genetic underpinnings of HRV.
  • Examine the genetic overlap among different HRV measurement domains (time, frequency, nonlinear dynamics).
  • Determine the phenotypic and genetic relationships between HRV and resting heart rate (HR).

Main Methods:

  • Electrocardiogram (ECG) recordings from a large, population-representative sample of young adult twins (n=1060).
  • Calculation of HRV measures across time, frequency, and nonlinear dynamics domains.
  • Linear structural equation modeling of twin data to estimate genetic and environmental influences.

Main Results:

  • HRV and HR variability are influenced by additive genetic and non-shared environmental factors (AE model).
  • Heritability estimates for HRV ranged from 47% to 64%, with high genetic overlap (>90%) across measurement domains.
  • Sex differences in heritability were noted for RMSSD (higher in males) and LF/HF (distinct genetic factors).
  • Approximately 40% of genetic variance in HRV was shared with HR.

Conclusions:

  • Both resting heart rate (HR) and heart rate variability (HRV) are highly heritable in young adults.
  • A substantial degree of genetic overlap exists across different HRV measurement domains.
  • Genetic influences on HRV show some sex-specific patterns, and share variance with HR.