Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integration of bulk RNA-seq and scRNA-seq reveals cell subsets and gene signatures associated with Glaesserella parasuis infection.

BMC genomics·2026
Same author

Preparation and Performance Analysis of a New Methanol-Mixed Gel Fuel Applied in Chemical Energy Storage.

ACS omega·2026
Same author

Landscape of N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) methylation in porcine cells identifies candidate genes associated with porcine epidemic diarrhea virus infection.

Frontiers in microbiology·2026
Same author

Spatiotemporally localized optical links and knots.

Nature communications·2026
Same author

Calcium-alginate microspheres for sustained curcumin delivery attenuate neuroinflammation and enhance nerve regeneration via suppressing NF-κB/MAPK pathways.

International journal of biological macromolecules·2026
Same author

Multi-omics integration analyses reveal microbiome and metabolome features in pregnant sow diarrhea induced by porcine epidemic diarrhea virus.

BMC microbiology·2026

Related Experiment Video

Updated: Mar 22, 2026

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.8K

Functionalized d-form self-assembling peptide hydrogels for bone regeneration.

Bin He1, Yunsheng Ou1, Ao Zhou1

  • 1Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Drug Design, Development and Therapy
|April 27, 2016
PubMed
Summary

This study shows that RGD-modified d-form peptide hydrogels significantly enhance bone regeneration in rat femoral condyle defects. These advanced scaffolds offer a promising solution for orthopedic bone grafting needs.

Keywords:
bone defectbone regenerationd-RADA16-RGDfunctionalized d-form self-assembling peptidepeptide hydrogel

More Related Videos

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids
10:23

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Published on: May 3, 2024

1.6K
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

12.0K

Related Experiment Videos

Last Updated: Mar 22, 2026

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.8K
Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids
10:23

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Published on: May 3, 2024

1.6K
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

12.0K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Bone defects present a significant clinical challenge in orthopedics, necessitating effective bone graft substitutes.
  • Current bone grafts face limitations such as immune rejection, poor osteoinduction, and suboptimal biocompatibility.
  • Self-assembling peptide nanofiber scaffolds show potential for bone regeneration applications.

Purpose of the Study:

  • To evaluate the structural characteristics and osteogenic capacity of d-RADA16-RGD peptide hydrogels.
  • To assess the efficacy of these peptide hydrogels in promoting bone regeneration in a rat femoral condyle defect model.
  • To investigate the role of d-form peptides and RGD modification in enhancing bone healing.

Main Methods:

  • Characterization of peptide hydrogels using Congo red staining, circular dichroism spectroscopy, transmission electron microscopy, and rheometry.
  • In vivo implantation of peptide hydrogels into femoral condyle defects in Sprague Dawley rats.
  • Assessment of bone regeneration via microcomputed tomography (micro-CT) and histological analyses.

Main Results:

  • D-RADA16-RGD peptide hydrogels exhibited favorable structural properties and stability.
  • RGD-modified d-form peptide scaffolds demonstrated enhanced osteogenic ability compared to controls.
  • Micro-CT and histological analyses confirmed significant bone regeneration in defects treated with RGD-modified scaffolds.

Conclusions:

  • RGD-modified d-form peptide hydrogels are effective substrates for promoting extensive bone regeneration.
  • These peptide scaffolds represent a promising biomaterial for orthopedic bone defect repair.
  • The use of d-form peptides and RGD modification improves scaffold performance for bone tissue engineering.