Related Experiment Video
Updated: Mar 22, 2026
13:07
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
4.7K
Infectious and coronary artery disease
Mohammad Saeid Rezaee-Zavareh1, Mohammad Tohidi1, Amin Sabouri1
1Researcher, Student Research Committee AND Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
ARYA Atherosclerosis
|April 27, 2016
Summary
Infections by certain microbes, including Helicobacter pylori, Chlamydia pneumoniae, and Cytomegalovirus, are strongly linked to coronary artery disease (CAD) risk. Controlling infections may help reduce atherosclerosis and CAD.
Area of Science:
- Cardiovascular Medicine
- Infectious Diseases
- Pathology
Background:
- Atherosclerotic events are a leading global cause of mortality.
- Coronary artery disease (CAD) is a significant manifestation of atherosclerosis.
- Traditional risk factors include diabetes mellitus, smoking, and hypertension; however, infections are increasingly recognized as contributing factors.
Purpose of the Study:
- To review the scientific literature on the association between infectious agents and atherosclerosis/CAD.
- To discuss the potential role of microbial infections in the development and progression of cardiovascular disease.
Main Methods:
- Comprehensive literature search conducted in PubMed, Scopus, and Science Direct.
- Keywords included atherosclerosis, CAD, myocardial infarction, infection, and specific microbial names.
- Reviewed studies correlating microbial agents with CAD risk.
Main Results:
- Several infectious agents (viruses, bacteria, parasites) are associated with CAD risk.
- Strong associations observed for Helicobacter pylori, Chlamydia pneumoniae, and Cytomegalovirus.
- Other agents, like influenza, require further investigation; diverse mechanisms link infections to CAD.
Conclusions:
- Evidence strongly suggests that microbial infections play a role in atherosclerosis.
- Managing infections, particularly in individuals with existing atherosclerosis risk factors, is crucial for reducing CAD risk.
Related Concept Videos
01:26Coronary Artery Disease II: Pathophysiology
937
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
937
01:30Coronary Artery Disease I: Introduction
1.6K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.6K
01:21Myocarditis I: Introduction
555
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
555
01:30Coronary Artery Disease III: Clinical Manifestations
545
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
545
01:26Coronary Artery Disease IV: Preventive Measures
837
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
837
01:25Endocarditis I: Introduction
717
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
717