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Infectious and coronary artery disease

Mohammad Saeid Rezaee-Zavareh1, Mohammad Tohidi1, Amin Sabouri1

  • 1Researcher, Student Research Committee AND Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

ARYA Atherosclerosis
|April 27, 2016
PubMed

Insights

Infections by certain microbes, including Helicobacter pylori, Chlamydia pneumoniae, and Cytomegalovirus, are strongly linked to coronary artery disease (CAD) risk. Controlling infections may help reduce atherosclerosis and CAD.

Area of Science:

  • Cardiovascular Medicine
  • Infectious Diseases
  • Pathology

Background:

  • Atherosclerotic events are a leading global cause of mortality.
  • Coronary artery disease (CAD) is a significant manifestation of atherosclerosis.
  • Traditional risk factors include diabetes mellitus, smoking, and hypertension; however, infections are increasingly recognized as contributing factors.

Purpose of the Study:

  • To review the scientific literature on the association between infectious agents and atherosclerosis/CAD.
  • To discuss the potential role of microbial infections in the development and progression of cardiovascular disease.

Main Methods:

  • Comprehensive literature search conducted in PubMed, Scopus, and Science Direct.
  • Keywords included atherosclerosis, CAD, myocardial infarction, infection, and specific microbial names.
  • Reviewed studies correlating microbial agents with CAD risk.

Main Results:

  • Several infectious agents (viruses, bacteria, parasites) are associated with CAD risk.
  • Strong associations observed for Helicobacter pylori, Chlamydia pneumoniae, and Cytomegalovirus.
  • Other agents, like influenza, require further investigation; diverse mechanisms link infections to CAD.

Conclusions:

  • Evidence strongly suggests that microbial infections play a role in atherosclerosis.
  • Managing infections, particularly in individuals with existing atherosclerosis risk factors, is crucial for reducing CAD risk.
Abstract

Keywords:
AtherosclerosisCoronary Artery DiseaseInfection

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