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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Capillaroscopy 2016: new perspectives in systemic sclerosis.

C Pizzorni, A Sulli, V Smith

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    This summary is machine-generated.

    Systemic sclerosis (SSc) involves early microvascular damage, with nailfold microangiopathy being a key indicator. This vascular impairment often precedes other symptoms, highlighting its predictive value in disease development.

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    Area of Science:

    • Rheumatology
    • Vascular Biology
    • Autoimmune Diseases

    Background:

    • Systemic sclerosis (SSc) is an autoimmune disease with unknown causes.
    • Early microvascular system impairment is a hallmark of SSc.
    • Nailfold microangiopathy and reduced peripheral blood flow are characteristic clinical features.

    Purpose of the Study:

    • To highlight the significance of microvascular injury in Systemic Sclerosis.
    • To discuss nailfold videocapillaroscopy as a primary diagnostic tool.
    • To review methods for assessing peripheral blood perfusion in SSc patients.

    Main Methods:

    • Nailfold videocapillaroscopy for evaluating peripheral capillary morphology and microangiopathy patterns.
    • Laser Doppler, laser speckle techniques, and thermography for assessing peripheral blood perfusion.

    Main Results:

    • Microangiopathy is a prominent feature in SSc, detectable via nailfold videocapillaroscopy.
    • Abnormalities in nailfold capillary morphology can predict disease progression.
    • Impaired peripheral blood perfusion is a consistent finding in SSc.

    Conclusions:

    • Nailfold microangiopathy is a crucial and early indicator of Systemic Sclerosis.
    • Videocapillaroscopy is essential for classifying and scoring SSc-related microangiopathy.
    • Assessing peripheral blood perfusion aids in understanding SSc pathophysiology.