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Updated: Mar 22, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Usability and Acceptability of a Web-Based Program for Chemotherapy-Induced Peripheral Neuropathy
Cindy Tofthagen1, Kevin E Kip, Denise Passmore
1Author Affiliations: University of South Florida, Tampa (Drs Tofthagen, Kip and Passmore and Mr Loy); and Dana-Farber Cancer Institute and Harvard Medical School in Boston, Massachusetts (Dr Berry).
A new web-based program, COPE-CIPN, shows promise for helping patients manage chemotherapy-induced peripheral neuropathy. It demonstrated good usability and acceptability, with a moderate effect on reducing daily life interference from symptoms.
Area of Science:
- Oncology
- Neurology
- Digital Health
Background:
- Chemotherapy-induced neuropathy (CIPN) is a significant adverse effect of cancer treatment.
- Existing self-management resources for CIPN are limited in accessibility and patient-centered design.
Purpose of the Study:
- To evaluate the usability and acceptability of a novel web-based intervention, the Creativity, Optimism, Planning, and Expert Information for Chemotherapy-Induced Peripheral Neuropathy (COPE-CIPN) program.
- To estimate the effect size of the COPE-CIPN on managing CIPN symptoms and their impact on daily activities.
Main Methods:
- A cohort of 14 participants used the COPE-CIPN program.
- Usability was assessed using the Post-Study System Usability Questionnaire.
- Acceptability was measured using the Acceptability e-Scale.
- Changes in CIPN symptom interference were tracked using the Chemotherapy Induced Peripheral Neuropathy Assessment Tool.
Main Results:
- The COPE-CIPN program achieved high usability (mean score 1.98) and acceptability (mean score 4.40).
- Participants found the interface easy to navigate and the information provided helpful.
- A moderate effect size (d = 0.39) was observed, with a decrease in the mean interference of CIPN symptoms with activities from 53.71 to 39.29 over 3-4 months.
Conclusions:
- The COPE-CIPN web-based intervention is usable and acceptable for patients experiencing chemotherapy-induced neuropathy.
- This digital tool shows potential as a supportive intervention for self-managing CIPN and mitigating its impact on quality of life.
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