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Acid Violet 17: a New Dye for Chromovitrectomy?
1Augenzentrum Klinik Pallas, Olten, Switzerland (Director: Prof. Dr. med. Heinrich Gerding, F. E. B. O.).
Klinische Monatsblatter Fur Augenheilkunde
|April 27, 2016
Summary
Acid Violet 17 (AV17) shows toxic effects at lower concentrations than marketed, with observed adverse clinical effects. Caution is advised when using this dye for intraocular procedures.
Area of Science:
- Ophthalmology
- Vitreoretinal Surgery
- Ocular Toxicology
Background:
- Acid Violet 17 (AV17) is a CE-certified dye for intraocular use in vitreoretinal interventions.
- This review synthesizes preclinical and clinical data on AV17's safety and efficacy.
Purpose of the Study:
- To evaluate the safety profile of Acid Violet 17 (AV17) for intraocular use.
- To review existing preclinical and clinical data regarding AV17's application in vitreoretinal surgery.
Main Methods:
- A systematic MEDLINE literature search was performed.
- Data from preclinical testing, cell cultures, organ cultures, and surgical procedures were analyzed.
Main Results:
- Preclinical data revealed toxic effects of AV17 on ocular cells at concentrations below 1.0 mg/ml.
- Observed adverse effects included retinal pigment epithelium degeneration and transient discoloration of intraocular lenses.
- One clinical case series reported no adverse effects, but dye application differed from labeling.
Conclusions:
- Preclinical data suggest AV17 possesses toxic and undesired effects at concentrations lower than those marketed.
- Clinical observations indicate potential adverse effects, warranting cautious use of AV17 in ophthalmic procedures.
