Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Respiratory Oscillometry in COPD Patients with Airway Mucus Plugs: Insights from the ECLIPSE Study.

American journal of respiratory and critical care medicine·2026
Same author

Rare coding variant architecture and gene discovery from 130,000 sequenced cases of atrial fibrillation.

Research square·2026
Same author

Corrigendum to "TFOS DEWS III: Digest" Am J Ophthalmol. 2025; 279:451-553.

American journal of ophthalmology·2026
Same author

AT2-intrinsic Z-AAT expression drives conserved inflammatory and proteotoxic stress responses and predisposes to emphysema.

bioRxiv : the preprint server for biology·2026
Same author

Polygenic risk and rare variants in endotypes of idiopathic pulmonary fibrosis: a genetic analysis of population-based and case-control cohorts.

The Lancet. Respiratory medicine·2026
Same author

Letting Biology Validate the EPR Imaging of Tumor pO<sub>2</sub>.

Advances in experimental medicine and biology·2026
Same journal

Impact of Subretinal Drusenoid Deposits on Ellipsoid Zone-Related Thickness Metrics.

Investigative ophthalmology & visual science·2026
Same journal

Proteomic Profiling of Optic Nerves From SMOX-Deficient Mice Identifies Regulators of Neuroinflammation and Axonal Damage in Optic Neuritis.

Investigative ophthalmology & visual science·2026
Same journal

Aflibercept and Faricimab Equipotently Restore Endothelial Barrier Function.

Investigative ophthalmology & visual science·2026
Same journal

Spatial Decomposition of Longitudinal RNFL Maps Reveals Distinct Modes of Glaucomatous Progression With Structure-Function and Genetic Signatures.

Investigative ophthalmology & visual science·2026
Same journal

The CXXC1-IGFBP6 Axis Maintains Corneal Epithelial Differentiation via H3K4me3-Dependent Transcriptional Activation.

Investigative ophthalmology & visual science·2026
Same journal

Archetypal Visual Field Analysis of Patients With Chronic Leber Hereditary Optic Neuropathy in Relation to Visual Recovery.

Investigative ophthalmology & visual science·2026
See all related articles

Related Experiment Video

Updated: Mar 22, 2026

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

2.0K

Engineering a Light-Attenuating Artificial Iris.

Farah J Shareef1, Shan Sun1, Mrignayani Kotecha1

  • 1Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, United States.

Investigative Ophthalmology & Visual Science
|April 27, 2016
PubMed
Summary
This summary is machine-generated.

A novel photo-responsive artificial iris, utilizing photochromic naphthopyrans, dynamically adjusts light transmission to improve vision for patients with iris damage. This adaptive lens offers a potential advancement over static commercial options.

More Related Videos

A System for Culturing Iris Pigment Epithelial Cells to Study Lens Regeneration in Newt
06:56

A System for Culturing Iris Pigment Epithelial Cells to Study Lens Regeneration in Newt

Published on: June 22, 2011

12.3K
Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis
06:57

Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis

Published on: March 8, 2018

9.4K

Related Experiment Videos

Last Updated: Mar 22, 2026

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

2.0K
A System for Culturing Iris Pigment Epithelial Cells to Study Lens Regeneration in Newt
06:56

A System for Culturing Iris Pigment Epithelial Cells to Study Lens Regeneration in Newt

Published on: June 22, 2011

12.3K
Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis
06:57

Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis

Published on: March 8, 2018

9.4K

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Optics

Background:

  • Iris damage from congenital conditions or trauma causes photophobia, glare, and vision impairment.
  • Current artificial iris lenses offer aesthetic benefits but lack dynamic light regulation.
  • A photo-responsive artificial iris is needed to restore natural light adaptation.

Purpose of the Study:

  • To develop and characterize a novel photo-responsive artificial iris.
  • To create a self-adaptive lens mimicking the natural iris's dynamic light transmission.
  • To assess the biocompatibility and safety of the new device.

Main Methods:

  • Engineered an artificial iris using a photochromic material (naphthopyrans, termed Photopia) embedded in polyethylene.
  • Fabricated annular disks coated with polydimethylsiloxane (PDMS) for controlled thickness.
  • Evaluated light attenuation, response time, and biocompatibility through in vitro cell culture and spectroscopy.

Main Results:

  • The artificial iris demonstrated rapid activation (approx. 5 seconds) and reversal (under 1 minute) to UV and blue light.
  • Achieved graded light attenuation of up to 40% visible and 60% UV light, regulating incident intensity.
  • Encapsulation prevented cell death, and spectroscopy confirmed no leakage of photochromic material, indicating biocompatibility.

Conclusions:

  • The developed artificial iris lens successfully mimics natural iris function by dynamically attenuating light.
  • Its rapid, reversible opacity changes offer a potential improved treatment for patients with iris damage.
  • The photo-responsive design addresses limitations of current static artificial iris prosthetics.