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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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[Male osteoporosis].

P Farahmand1, R Spiegel2, J D Ringe3

  • 1Medizinische Klinik II, Nephrologie und Nierentransplantation, Universitätsklinikum Gießen und Marburg GmbH, Standort Gießen, Klinikstr. 33, 35392, Gießen, Deutschland. parvis@farahmand.de.

Zeitschrift Fur Rheumatologie
|April 28, 2016
PubMed
Summary
This summary is machine-generated.

Male osteoporosis is a significant health issue, often underdiagnosed and undertreated despite high fracture mortality. Early diagnosis and diverse therapeutic options are crucial for effective management in men.

Keywords:
DiagnosticsFractureMenMortalityOsteoporosisRisk factorsTherapy

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Area of Science:

  • Endocrinology and Metabolic Bone Diseases
  • Public Health
  • Geriatrics

Background:

  • Osteoporosis in men represents a substantial public health concern, particularly in Germany, with over one million cases.
  • Despite higher mortality rates from osteoporotic fractures in men compared to women, male patients remain underdiagnosed and undertreated.

Purpose of the Study:

  • To review the epidemiology of male osteoporosis.
  • To discuss current treatment strategies, hormonal pathophysiology, risk factors, diagnostic approaches, and therapeutic options.

Main Methods:

  • A comprehensive overview of existing data on male osteoporosis.
  • Recommendations for diagnostic work-up procedures.
  • Presentation of the current landscape of pharmaceutical therapies.

Main Results:

  • Risk factors for osteoporosis are identified in 50-70% of male patients, necessitating thorough patient history assessment.
  • Radiological imaging of the spine is recommended to detect vertebral fractures, affecting approximately 10% of men over 50.
  • Laboratory tests aid in excluding other metabolic bone diseases, while various medications like bisphosphonates, denosumab, and teriparatide are available for treatment.

Conclusions:

  • Male osteoporosis is increasingly recognized as a critical public health issue requiring adequate diagnosis and treatment.
  • A wide array of therapeutic options with distinct mechanisms of action enables individualized treatment strategies for male osteoporosis patients.