Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.9K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.9K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

7.5K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radioligand therapy in combination with CAR T cells overcomes the heterogeneous immunosuppressive prostate tumor microenvironment.

bioRxiv : the preprint server for biology·2026
Same author

Illustration of transfer learning from breast cancer detection to risk prediction: adaptation to local data and local objectives.

Journal of medical imaging (Bellingham, Wash.)·2026
Same author

Integrating imaging and mathematical modeling to predict and optimize patient outcomes in oncology.

NPJ systems biology and applications·2026
Same author

Mathematical modeling of neural stem cell migration within brain using multi-fiber tractography.

Mathematical biosciences·2026
Same author

Integrating biomarker-derived individual treatment response assessment into Bayesian trial design for personalized cancer treatment.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Probabilistic clinical target definition with nearest neighbor correlation.

Physics in medicine and biology·2025

Related Experiment Video

Updated: Mar 22, 2026

Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research
07:26

Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research

Published on: September 15, 2023

2.6K

An imaging-based computational model for simulating angiogenesis and tumour oxygenation dynamics.

Vikram Adhikarla1, Robert Jeraj

  • 1Department of Physics, University of Wisconsin, Madison, WI, USA. Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.

Physics in Medicine and Biology
|April 28, 2016
PubMed
Summary

This study developed a computational model to simulate tumor oxygenation using molecular imaging data. The model accurately predicts tumor oxygenation dynamics, crucial for understanding tumor growth and treatment response.

More Related Videos

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
07:07

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Published on: February 14, 2025

4.0K
Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
10:23

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

1.1K

Related Experiment Videos

Last Updated: Mar 22, 2026

Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research
07:26

Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research

Published on: September 15, 2023

2.6K
Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
07:07

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Published on: February 14, 2025

4.0K
Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
10:23

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

1.1K

Area of Science:

  • Computational modeling
  • Molecular imaging
  • Tumor biology

Background:

  • Tumor growth, angiogenesis, and oxygenation are critical factors influencing treatment outcomes.
  • Significant variations in these characteristics exist among different tumors.
  • Molecular imaging offers a unique approach to investigate tumor-specific properties.

Purpose of the Study:

  • To propose and validate a computational model for simulating tumor-specific oxygenation changes.
  • To link tumor oxygenation to perfused vessel density, tumor doubling time, and vascular endothelial growth factor (VEGF) concentration.
  • To assess the model's ability to reproduce tumor oxygenation dynamics throughout its lifecycle.

Main Methods:

  • Development of a computational model integrating molecular imaging data.
  • Quantification of tumor oxygenation dynamics using peak partial pressure of oxygen (pO2peak) and time to peak pO2 (t peak).
  • Sensitivity analysis of model parameters, including tumor doubling time, tissue vasculature density, and VEGFmax.

Main Results:

  • The model successfully reproduced tumor oxygenation dynamics over the tumor lifecycle.
  • Tumor oxygenation dynamics were found to be more sensitive to tumor cell doubling time than tissue vasculature density.
  • VEGFmax had a marginal effect on both pO2peak and t peak, while tumor growth led to increased hypoxia.

Conclusions:

  • The developed computational model provides a robust tool for analyzing tumor evolution using tumor-specific data.
  • The model's ability to simulate tumor oxygenation dynamics is crucial for understanding treatment outcomes.
  • Future extensions of the model can aid in evaluating anti-angiogenic therapies.