[Various aspects of the interrelations between blood phospholipids, blood coagulation and microcirculation in chronic...

Studies of conjunctival microcirculation, thromboelastographic coagulation (as assessed by 8 parameters) and plasma phospholipid spectrum (with 8 fractions obtained), carried out in 136 patients with acute phases of chronic bronchitis, have demonstrated considerable disorders of microcirculation, hypercoagulation and shifts of blood phospholipid spectrum. Marked perivascular disorders were matched by increased levels of plasma lysophosphatidylcholines, which promote increased capillary permeability. Intravascular changes (erythrocyte aggregation and sludging, intermittent flow and stasis of blood) were accompanied by established hypercoagulation and increased phosphatidylethanolamines, producing a coagulating effect. A drop in plasma phosphatidylcholines is a symptom of disrupted synthesis of this phospholipid class in the lungs, and a disorder of pulmonary surfactant structure and function. The level of phosphatidylserins, conducive to histamine release by mast cells, rose in patients with the bronchospastic syndrome. Shifts in other phospholipid fractions, typical for different types and stages of chronic bronchitis, have also been demonstrated. Basically, the magnitude of shifts was greater prior to treatment in the majority of parameters.