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Published on: January 30, 2020
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Bremsstrahlung radiation detection for small animal imaging using a CCD detector.
Antonello E Spinelli1, Federico Boschi2
1Experimental Imaging Centre, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy.
Summary
This study demonstrates that optical imaging systems can detect planar bremsstrahlung radiation images from radionuclides. This method shows potential for preclinical molecular imaging applications.
Area of Science:
- Medical Imaging
- Nuclear Medicine
- Optical Physics
Background:
- Optical methods are increasingly used in preclinical molecular imaging.
- Detection of radionuclides is crucial for molecular imaging.
- Bremsstrahlung radiation is a byproduct of beta decay.
Purpose of the Study:
- To investigate the feasibility of using a small animal optical imager to detect planar bremsstrahlung radiation images.
- To demonstrate proof-of-principle for optical detection of radionuclide emissions.
Main Methods:
- A bremsstrahlung source was created using a Phosphorus-32-ATP vial.
- The source and an intensifying screen were placed in a small animal optical imaging system.
- Images were acquired with and without an object (pliers) between the source and screen.
Main Results:
- Planar bremsstrahlung radiation images were successfully detected using the optical imager and intensifying screen.
- The absorption image of the pliers accurately reflected the object's shape.
- The spatial resolution was limited by a significant penumbra effect.
Conclusions:
- Optical imaging devices can be utilized to produce planar bremsstrahlung images.
- This technique shows promise for preclinical radionuclide detection and molecular imaging.
