Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...

Self-Regulation

Self-Regulation

Self-regulation, also known as self-control, encompasses a range of cognitive and behavioral processes that allow individuals to adjust their internal states and outward actions to align with socially acceptable norms and long-term goals. It plays a fundamental role in adaptive functioning, from resisting impulsive behaviors to persisting through challenging tasks. While its benefits are widely recognized, self-regulation is not limitless. Muraven and Baumeister's theory posits that...

Hedgehog Signaling Pathway

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Loss of GABAergic transmission from somatostatin neurons leads to starvation, which is attenuated by a palatable diet.

Life sciences·2026

Same author

Vesicular GABA transport expression in kisspeptin cells may contribute to the preovulatory gonadotropin surge.

Frontiers in endocrinology·2026

Same author

The bottleneck of fat burning.

Science (New York, N.Y.)·2026

Same author

Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance.

Nature metabolism·2026

Same author

KNDy neurons as an indirect target of insulin-like growth factor-1.

Journal of neuroendocrinology·2025

Same author

Nutritionally Responsive PMv DAT Neurons Are Dynamically Regulated During Pubertal Transition.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2025

Search research articles

Related Experiment Video

Updated: Mar 22, 2026

Applying Stereotactic Injection Technique to Study Genetic Effects on Animal Behaviors

Applying Stereotactic Injection Technique to Study Genetic Effects on Animal Behaviors

Published on: May 10, 2015

Brain STAT5 signaling and behavioral control.

Isadora C Furigo¹, Angela M Ramos-Lobo¹, Renata Frazão²

¹Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, 05508-000, Brazil.

Molecular and Cellular Endocrinology

|April 28, 2016

Summary

This summary is machine-generated.

The signal transducer and activator of transcription 5 (STAT5) pathway regulates motivated behaviors in the brain. This review explores STAT5

Keywords:

Feeding Growth hormone Hypothalamus Leptin Maternal behavior Prolactin

More Related Videos

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments

A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments

Published on: April 15, 2014

Related Experiment Videos

Last Updated: Mar 22, 2026

Applying Stereotactic Injection Technique to Study Genetic Effects on Animal Behaviors

Applying Stereotactic Injection Technique to Study Genetic Effects on Animal Behaviors

Published on: May 10, 2015

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments

A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments

Published on: April 15, 2014

Area of Science:

Neuroscience
Molecular Biology
Endocrinology

Background:

Signal transducer and activator of transcription 5 (STAT5) pathway is involved in cell growth and differentiation.
The role of STAT5 in brain function and behavior is not well understood.
Hormones like prolactin and leptin activate STAT5 in the brain, influencing motivated behaviors.

Purpose of the Study:

To review and discuss the role of central STAT5 signaling in regulating brain functions.
To focus on the involvement of STAT5 in behavioral control, particularly motivated behaviors.
To summarize existing data on STAT5's influence on maternal and feeding behaviors.

Main Methods:

Literature review of studies investigating STAT5 signaling in the brain.
Analysis of research on STAT5's role in maternal and feeding behaviors.
Exploration of potential effects of STAT5 on other behaviors.

Main Results:

STAT5 signaling is implicated in the regulation of maternal and feeding behaviors.
Evidence suggests STAT5 influences various motivated behaviors.
The precise mechanisms of STAT5 in behavioral modulation are still under investigation.

Conclusions:

Central STAT5 signaling plays a significant role in regulating motivated behaviors.
Understanding STAT5 pathways is crucial for deciphering the cellular basis of motivated behaviors.
Further research is needed to fully elucidate STAT5's complex role in brain function and behavior.