Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Malic enzyme activity in the developing rat brain in relation to thyroid status.

U R Thakare1, D H Shah, U Vijayan

  • 1Radiation Medicine Centre, BARC, Tata Memorial Centre Annexe, Parel, Bombay, India.

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
|January 1, 1989
PubMed
Summary

Thyroid hormones are crucial for developing brains, regulating malic enzyme activity in neonates. This enzyme

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Changes in cellular structure of heat-treated Salmonella in low-moisture environments.

Journal of applied microbiology·2020
Same author

Rapid differentiation of Mycobacterium bovis and Mycobacterium tuberculosis based on a 12.7-kb fragment by a single tube multiplex-PCR.

Veterinary microbiology·2005
Same author

A multiplex-PCR for the differentiation of Mycobacterium bovis and Mycobacterium tuberculosis.

FEMS microbiology letters·2002
Same author

Hospital morbidity due to post-operative infections in obstetrics & gynecology.

Saudi medical journal·2001
Same author

Tonsillolith: a case report.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons·2001
Same author

Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2.

Bioorganic & medicinal chemistry letters·2001

Area of Science:

  • Neuroendocrinology
  • Developmental Biology
  • Biochemistry

Background:

  • Thyroid hormones play a vital role in brain development.
  • Malic enzyme is a key metabolic enzyme involved in lipogenesis and neurotransmitter synthesis.
  • Disruptions in thyroid hormone levels during gestation can impact fetal brain development.

Purpose of the Study:

  • To investigate the role of thyroid hormones in regulating malic enzyme activity during critical periods of brain maturation.
  • To determine if propylthiouracil-induced hypothyroidism affects malic enzyme activity in neonate brains.
  • To assess the reversibility of these effects with triiodothyronine supplementation.

Main Methods:

  • Pregnant rats were administered propylthiouracil (PTU) in drinking water from day 12 of gestation.

Related Experiment Videos

  • Malic enzyme activity was measured in the soluble fraction of neonate brains.
  • Triiodothyronine (T3) was administered to neonates from PTU-exposed mothers and to control adult rats.

    • Main Results:

    • Propylthiouracil exposure significantly lowered malic enzyme activity in neonate brains.
    • Triiodothyronine supplementation normalized malic enzyme activity in neonates from PTU-exposed mothers.
    • Triiodothyronine administration did not affect malic enzyme activity in mature adult rat brains.

    Conclusions:

    • Malic enzyme activity in the developing brain is under the control of thyroid hormones during critical maturation periods.
    • The sensitivity of malic enzyme to thyroid hormones is lost in the mature brain.
    • These findings highlight the critical impact of thyroid hormone status during gestation on neonatal brain metabolism.