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Updated: Mar 22, 2026

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Photoletter to the editor: Postradiation sarcoma.

Cristina Garrido-Colmenero1, Ignacio Valenzuela-Salas1, Gonzalo Blasco-Morente1

  • 1Dermatology Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain;

Journal of Dermatological Case Reports
|April 28, 2016
PubMed
Summary

Postradiation sarcomas are rare, highly malignant tumors developing after radiotherapy. This case highlights a malignant fibrous histiocytoma appearing 35 years post-treatment for a leg melanoma.

Keywords:
malignant fibrous histiocytomapostradiationradiotherapysarcoma

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Surgical Pathology

Background:

  • Postradiation sarcomas are uncommon but aggressive malignancies.
  • These tumors can arise from bone or soft tissues following radiation therapy.
  • The latency period between radiotherapy and sarcoma development can be prolonged.

Purpose of the Study:

  • To report a rare case of postradiation sarcoma.
  • To emphasize the long-term risk of secondary malignancies after radiotherapy.
  • To discuss the clinical presentation and characteristics of malignant fibrous histiocytoma.

Main Methods:

  • Case report detailing a patient's medical history.
  • Review of clinical presentation and diagnostic findings.
  • Histopathological examination for tumor characterization.

Main Results:

  • A patient developed a malignant fibrous histiocytoma.
  • The sarcoma manifested 35 years after radiotherapy for melanoma.
  • The tumor originated in the soft tissues of the right leg.

Conclusions:

  • Malignant fibrous histiocytoma can occur decades after radiation exposure.
  • Long-term surveillance is crucial for patients treated with radiotherapy.
  • Understanding the latency of postradiation sarcomas is important for patient management.