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Updated: Mar 22, 2026

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
Published on: June 20, 2017
[Mental disorders after mild traumatic brain injury]
A S Gonschorek1, P Schwenkreis2, T Guthke3
1Berufsgenossenschaftliches Klinikum Hamburg, Neurotraumatologisches Zentrum, Bergedorfer Str. 10, 21033, Hamburg, Deutschland. a.gonschorek@bgk-hamburg.de.
Abstract:
Mild traumatic brain injury (mTBI) is a frequent neurological disorder following a closed head injury. It is often accompanied by temporary changes of consciousness as well as cognitive, emotional and physical symptoms. These symptoms subside in the vast majority of affected persons within a few weeks; however, in recent years it has become increasingly more apparent that functionally significant long-term effects can remain after an initially diagnosed mTBI. In these cases mental disorders, such as impairment of cognitive and emotional functions as well as somatic disorders play an important role. This article presents the frequency, diagnosis, therapy and possible mechanisms of cognitive and emotional dysfunction after mTBI, including medicolegal aspects.
Insights
Mild traumatic brain injury (mTBI) can cause lasting cognitive and emotional issues, even after initial recovery. This review covers mTBI
Area of Science:
- Neurology
- Neuroscience
- Psychiatry
Background:
- Mild traumatic brain injury (mTBI) is a common neurological disorder from head injuries.
- While most symptoms resolve within weeks, significant long-term effects are increasingly recognized.
- These long-term effects can include cognitive, emotional, and somatic disorders.
Purpose of the Study:
- To review the frequency, diagnosis, and therapy of cognitive and emotional dysfunction post-mTBI.
- To explore potential mechanisms underlying these long-term deficits.
- To discuss medicolegal considerations associated with mTBI.
Main Methods:
- Literature review of studies on mTBI.
- Analysis of diagnostic criteria and therapeutic interventions.
- Examination of neurobiological and psychological mechanisms.
Main Results:
- mTBI can lead to persistent cognitive and emotional impairments.
- Diagnosis requires careful assessment beyond initial recovery.
- Therapeutic strategies are evolving to address long-term sequelae.
Conclusions:
- Long-term cognitive and emotional dysfunction is a significant outcome of mTBI.
- Comprehensive management and understanding of mechanisms are crucial.
- Further research is needed to optimize treatment and address medicolegal aspects.
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