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Ansalactams B-D Illustrate Further Biosynthetic Plasticity within the Ansamycin Pathway
Tu Cam Le1, Inho Yang1, Yeo Joon Yoon1
1Department of Chemistry and Nano Science, Global Top 5 program, Ewha Womans University , Seoul 03760, Korea.
Abstract:
Further chemical investigation of a marine-derived bacterium of the genus Streptomyces has led to the isolation of ansalactams B-D (1-3) along with the previously reported metabolite ansalactam A (4). Ansalactams B-D are significantly modified ansamycins, representing three new carbon skeletons and further illustrating the biosynthetic plasticity of the ansalactam class. Unlike ansalactam A, ansalactams B and D are penta- and hexacyclic metabolites, while ansalactam C illustrates an open polyene chain with a terminal carboxylic acid.
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