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Perispinal Delivery of CNS Drugs
1Institute of Neurological Recovery, 2300 Glades Road, Suite 305E, Boca Raton, FL, 33431, USA. nrimed@gmail.com.
CNS Drugs
|April 28, 2016
Summary
Perispinal injection offers a novel route for delivering drugs to the central nervous system (CNS), bypassing physiological barriers. This method utilizes the cerebrospinal venous system (CSVS) for enhanced drug delivery, showing potential for treating CNS disorders.
Area of Science:
- Neuroscience
- Anatomy
- Pharmacology
Background:
- Physiological barriers limit drug delivery to the central nervous system (CNS) via systemic administration.
- Perispinal injection leverages the cerebrospinal venous system (CSVS) for enhanced CNS drug delivery.
- Historical anatomical studies by Breschet and Batson underpin the perispinal injection method.
Purpose of the Study:
- To introduce perispinal injection as a novel method for drug delivery to the CNS.
- To highlight the anatomical basis and historical context of perispinal injection.
- To explore the therapeutic potential of perispinal injection for CNS disorders.
Main Methods:
- Injection into the anatomic area posterior to the ligamentum flavum.
- Utilizing the external vertebral venous plexus (EVVP), a division of the CSVS.
- Review of historical anatomical findings by Breschet, Batson, and Corning.
Main Results:
- Perispinal injection enhances drug delivery to the CNS by utilizing the CSVS.
- Historical analysis suggests perispinal injection was used for spinal anesthesia.
- Rapid neurological improvement observed in patients with neuroinflammatory disorders treated with perispinal etanercept.
Conclusions:
- Perispinal injection is a promising novel method for CNS drug delivery.
- The CSVS provides a viable pathway for macromolecules to reach the CNS.
- Further investigation into perispinal delivery is warranted for CNS disorders.
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