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High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
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[Not Available].

N Massager, S Lonneville, B Mine

    Revue Medicale De Bruxelles
    |April 29, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Gamma Knife radiosurgery effectively treats brain arteriovenous malformations (AVM), achieving a 96% cure rate in 123 patients. This efficient, low-risk therapy is best utilized by a multidisciplinary team.

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    Area of Science:

    • Neurosurgery
    • Radiation Oncology
    • Radiology

    Context:

    • Arteriovenous malformations (AVM) are complex vascular abnormalities in the brain.
    • Gamma Knife radiosurgery has been used for AVM treatment for approximately 40 years.
    • Treatment decisions are guided by multidisciplinary team discussions based on AVM-specific parameters.

    Purpose:

    • To present the outcomes of 123 patients treated for brain AVM at the Gamma Knife Center ULB-Hôpital Erasme.
    • To evaluate the efficacy and safety of Gamma Knife radiosurgery for AVM obliteration.
    • To analyze factors influencing treatment success and patient outcomes.

    Summary:

    • Gamma Knife irradiation was applied to AVM residues in 123 patients, often after prior embolization (84%) or microsurgery (7%).
    • A mean margin dose of 22.3 Gy was delivered to the nidus (mean volume 3.3 cc).
    • Complete AVM obliteration was achieved in 89% of patients after a mean of 32 months, with an overall 96% cure rate after one or two sessions.

    Impact:

    • Gamma Knife treatment demonstrated high efficacy (96% cure rate) with a low risk of permanent neurological worsening (4%).
    • The study highlights the importance of a multidisciplinary approach in optimizing AVM treatment strategies.
    • This therapy offers a safe and effective option for managing cerebral arteriovenous malformations.