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Transabdominal chorionic villus sampling for first-trimester prenatal diagnosis
S Elias1, J L Simpson, L P Shulman
1Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38163.
American Journal of Obstetrics and Gynecology
|April 1, 1989
Summary
Transabdominal chorionic villus sampling offers a safe and effective method for first-trimester prenatal diagnosis. This technique achieved a high success rate, providing valuable genetic information for expectant mothers.
Area of Science:
- Medical Genetics
- Prenatal Diagnosis
- Obstetrics & Gynecology
Background:
- First-trimester prenatal diagnosis is crucial for early detection of fetal genetic abnormalities.
- Transabdominal chorionic villus sampling (CVS) is an alternative to transcervical CVS.
Purpose of the Study:
- To report the technique and initial experience with transabdominal CVS for first-trimester prenatal diagnosis.
- To evaluate the safety and efficacy of the transabdominal approach.
Main Methods:
- Eighty-seven pregnant patients underwent transabdominal CVS between 9 and 12 menstrual weeks.
- Sufficient chorionic villi samples (≥5 mg) were obtained in 95.4% of cases.
- Single needle passage was sufficient in 88% of successful samplings.
Main Results:
- Genetic diagnoses included Down syndrome (47,XX,+21), a balanced translocation (46,XX,rcp(15;21)), and mosaic trisomy 16 (47,XX,+16).
- One case of trisomy 16 was a false positive, with a normal karyotype confirmed by amniocentesis.
- 39 deliveries resulted in healthy infants; 44 pregnancies continue uneventfully.
Conclusions:
- Transabdominal CVS is a viable alternative to transcervical CVS.
- It is particularly useful when the transcervical route is contraindicated or technically challenging.