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Vitamin D levels in children with familial Mediterranean fever

Hatice Onur1, Hale Aral2, Vefik Arica3

  • 1Department of Pediatrics, Bursa Yuksek Ihtisas Training and Research Hospital, 152 Evler, Prof. Tezok street No: 2, Yıldırım/Bursa, Istanbul, Turkey. drhaticeakar@gmail.com.

Pediatric Rheumatology Online Journal
|April 29, 2016
PubMed

Insights

Children with familial Mediterranean fever (FMF) have lower vitamin D levels than healthy children. This suggests vitamin D deficiency screening and supplementation may be beneficial for FMF patients.

Area of Science:

  • Pediatrics
  • Immunology
  • Endocrinology

Background:

  • Familial Mediterranean fever (FMF) is a genetic autoinflammatory disease.
  • Vitamin D plays a crucial role in immune function and bone health.
  • The relationship between FMF and vitamin D status is not well-established.

Purpose of the Study:

  • To investigate the prevalence of vitamin D deficiency in children diagnosed with FMF.
  • To compare vitamin D levels in pediatric FMF patients with healthy controls.

Main Methods:

  • A case-control study involving 100 children with FMF and 50 healthy children.
  • Measurement of serum 25-hydroxyvitamin D levels.
  • Analysis of demographic and clinical parameters, including MEFV mutations and parathyroid hormone levels.

Main Results:

  • Children with FMF exhibited significantly lower serum vitamin D levels compared to healthy controls (24.78 vs. 28.70 ng/mL, P=0.039).
  • Vitamin D levels did not differ significantly across various MEFV mutations (P=0.633).
  • A significant negative correlation was observed between vitamin D levels and parathyroid hormone (rs=-0.382, P<0.0001), and age (r=-0.235, P=0.019).

Conclusions:

  • Pediatric patients with FMF demonstrate lower vitamin D levels than their healthy peers.
  • Routine assessment of vitamin D status and potential supplementation are recommended for children with FMF.
  • Further large-scale studies are warranted to confirm the incidence of vitamin D deficiency in FMF.
Abstract

Keywords:
25-hydroxyvitamin DChildrenFamilial Mediterranean feverGene mutation

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