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Updated: Mar 22, 2026
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Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
Published on: April 7, 2020
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Metabolomic patterns associated to QTc interval in shiftworkers: an explorative analysis.
Marcello Campagna1, Emanuela Locci1, Roberto Piras1
1a Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Summary
Shiftworkers show altered QTc intervals linked to metabolic changes. This study identifies potential early markers like body mass index, glycemia, lactate, pyroglutamate, and 3-hydroxybutyrate for shiftworker health monitoring.
Area of Science:
- Biochemistry
- Cardiology
- Occupational Health
Background:
- Shift work is associated with cardiovascular risks.
- The QTc interval is a marker of cardiac repolarization.
- Metabolic dysregulation is common in shiftworkers.
Purpose of the Study:
- To investigate the correlation between the QTc interval and plasma metabolic profiles in shiftworkers.
- To identify potential metabolic biomarkers associated with QTc interval changes in this population.
Main Methods:
- Utilized a (1)H NMR-metabolomic approach.
- Collected socio-demographic data, QTc interval, and plasma metabolic profiles from 32 male shiftworkers.
- Employed multivariate regression analysis for correlations.
Main Results:
- Positive correlation found between QTc interval and body mass index, glycemia, and lactate levels.
- Negative correlation observed between QTc interval and pyroglutamate and 3-hydroxybutyrate plasma levels.
Conclusions:
- Shiftworkers exhibit associations between clinical and metabolic profiles and QTc interval values.
- Identified metabolic markers may indicate early effects or susceptibility in shiftworkers.
- Findings support the use of metabolic profiling for monitoring shiftworker health.
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