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Related Experiment Video

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Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation
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Quantification of maceration changes using post mortem MRI in fetuses.

P Montaldo1, S Addison2, V Oliveira2

  • 1Centre for Perinatal Neuroscience, Imperial College London, Du Cane Road, London, W12 0HS, UK. p.montaldo@imperial.ac.uk.

BMC Medical Imaging
|April 29, 2016
PubMed
Summary
This summary is machine-generated.

Post mortem magnetic resonance imaging (PMMR) effectively identifies fetal maceration, correlating well with autopsy findings. This imaging technique aids in interpreting post-mortem changes in fetuses.

Keywords:
AutopsyFetusesIntrauterine deathMRIMacerationPathology

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Area of Science:

  • Medical Imaging
  • Pathology
  • Forensic Medicine

Background:

  • Post mortem imaging is crucial for perinatal autopsy interpretation.
  • Fetal maceration following intra-uterine fetal death requires accurate assessment.
  • This study evaluates post mortem magnetic resonance imaging (PMMR) for detecting maceration.

Purpose of the Study:

  • To determine if PMMR findings correlate with fetal maceration observed during conventional autopsy.
  • To assess the utility of PMMR in evaluating post-mortem changes in fetuses.

Main Methods:

  • Seventy-five fetuses underwent pre-autopsy PMMR using a 1.5 Tesla scanner.
  • PMMR images were scored for maceration severity in 6 visceral organs, blinded to autopsy data.
  • Quantitative T2 maps of the liver and lungs were generated.

Main Results:

  • A strong correlation (R²=0.93) was found between PMMR maceration scores and autopsy scores.
  • PMMR demonstrated 91% sensitivity and 64% specificity for moderate/severe maceration.
  • Increased liver and lung T2 values were associated with higher maceration scores.

Conclusions:

  • PMMR provides a reliable assessment of fetal maceration, correlating well with conventional autopsy findings.
  • The PMMR maceration score is a valuable tool for interpreting post-mortem changes in fetuses.