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Updated: Mar 22, 2026

An in vivo Rodent Model of Contraction-induced Injury and Non-invasive Monitoring of Recovery
Published on: May 11, 2011
Neurotrophic and Neuroprotective Effects of Muscle Contraction
Valentina Arnao1, Domenico Di Raimondo, Antonino Tuttolomondo
1Valentina Arnao U. O di Neurologia e Neurofisiopatologia, Università degli Studi di Palermo, Via G. La Loggia n 1, 90129 - Italy. arnao.valentina@gmail.com.
Background:
Physical activity has been shown to be associated with reduced risk of coronary heart disease but the same effect seems to be produced in neurological diseases.
Objective:
In this review, we focused on the interplay between physical activity and some neurological conditions (Stroke, dementia, epilepsy, headache, Parkinson' s disease, amyotrophic lateral sclerosis, multiple sclerosis, insomnia, depression and anxiety) with the aim of describing the potential role of physical activity in the prevention of such diseases and the physiological mechanisms involved in these processes.
Results:
Despite a growing body of evidence which reveals that physical activity is able to reduce the frequency of neurological diseases, directly or indirectly by enhancing cardiovascular conditions, further studies are necessary to better characterize which type of exercise is useful for each condition.
Conclusion:
Physical activity could represent an additional approach to fight against such diseases.
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