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Updated: Mar 22, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Genetic susceptibility to the endemic form of NPC
Jin-Xin Bei1, Xiao-Yu Zuo2, Wen-Sheng Liu2
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060, China; Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. beijx@sysucc.org.cn.
Abstract:
Nasopharyngeal carcinoma (NPC) is a malignancy with remarkably high prevalence in East Asia. Lines of evidence have suggested the involvement of genetic lesions in the etiology of NPC, together with the contributions of Epstein-Barr virus infection and environmental exposures. Linkage and association studies, either based on candidate genes or genome-wide levels, have been conducted to dissect the genetic variants that contribute to NPC risk. This review summarizes the current findings of genetic susceptibility to NPC, and points out some future challenges on discovery of other risk variants to explain the missing heritability of NPC.
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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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Translation
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