Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Approaches to mixture risk assessment of PFASs in the European population based on human hazard and biomonitoring data.

International journal of hygiene and environmental health·2022

Same author

Dietary Inflammatory Index and Cross-Sectional Associations with Inflammation, Muscle Mass and Function in Healthy Old Adults.

The journal of nutrition, health & aging·2022

Same author

In situ observations show vertical community structure of pelagic fauna in the eastern tropical North Atlantic off Cape Verde.

Scientific reports·2020

Same author

Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - Evolution versus revolution.

Toxicology in vitro : an international journal published in association with BIBRA·2019

Same author

[Hypothalamic intravascular B-cell lymphoma in an immunocompetent patient].

Revista de neurologia·2019

Same author

Complementary cathodoluminescence lifetime imaging configurations in a scanning electron microscope.

Ultramicroscopy·2018

Search research articles

Related Experiment Video

Updated: Mar 22, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Multiple Endocrine Disrupting Effects in Rats Perinatally Exposed to Butylparaben.

J Boberg¹, M Axelstad², T Svingen²

¹National Food Institute, Technical University of Denmark, Søborg, Denmark jubo@food.dtu.dk.

Toxicological Sciences : an Official Journal of the Society of Toxicology

|April 29, 2016

Summary

Butylparaben, a common preservative, disrupts endocrine systems in developing rats, affecting reproductive development and sperm counts even at low doses. This study highlights its potential risks for both male and female offspring.

Keywords:

breast endocrine disruption paraben prostate reproduction sexual development testis

More Related Videos

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

Sectioning Mammary Gland Whole Mounts for Lesion Identification

Sectioning Mammary Gland Whole Mounts for Lesion Identification

Published on: July 24, 2017

Related Experiment Videos

Last Updated: Mar 22, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

Sectioning Mammary Gland Whole Mounts for Lesion Identification

Sectioning Mammary Gland Whole Mounts for Lesion Identification

Published on: July 24, 2017

Area of Science:

Endocrinology
Developmental Toxicology
Environmental Health

Background:

Parabens are widely used preservatives in consumer products.
Butylparaben exhibits estrogenic and antiandrogenic properties.
Previous studies linked butylparaben to reduced sperm counts in male rats.

Purpose of the Study:

To investigate the effects of perinatal butylparaben exposure on endocrine-sensitive endpoints in Wistar rats.
To determine if butylparaben affects reproductive development and steroidogenesis in offspring.

Main Methods:

Oral exposure of time-mated Wistar rats to butylparaben (0, 10, 100, 500 mg/kg bw/d) from gestation day 7 to pup day 22.
Evaluation of endocrine-sensitive endpoints including anogenital distance, ovary weight, mammary gland outgrowth, sperm count, and gene expression (CYP19a1, Nr5a1).
Histological examination of prostate tissue and measurement of prostate weight.

Main Results:

Reduced anogenital distance in both male and female offspring at higher doses.
Decreased ovary weights and increased mammary gland outgrowth in prepubertal females.
Significant reduction in sperm count in males at all tested doses (≥10 mg/kg bw/d).
Altered testicular CYP19a1 expression in prepubertal rats and reduced Nr5a1 expression in adult testes.
Prostate histology alterations and reduced adult prostate weight in the high-dose group.

Conclusions:

Perinatal butylparaben exposure exerts adverse endocrine-disrupting effects on both male and female rat offspring.
The lowest observed adverse effect level for developmental toxicity on sperm count is 10 mg/kg bw/d.
Findings are significant for risk assessment of butylparaben exposure during development.