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Updated: Mar 22, 2026

Synovial Fluid Analysis to Identify Osteoarthritis
Published on: October 20, 2022
Plasma and synovial fluid inflammatory cytokine profiles in primary knee osteoarthritis
Thomas Mabey1, Sittisak Honsawek1,2, Aree Tanavalee2
1a Department of Biochemistry, Faculty of Medicine , Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society , Bangkok , Thailand ;
Objective:
The objective of this study is to compare inflammatory cytokine levels in primary knee osteoarthritis (OA) patients and healthy controls.
Methods:
A total of 32 knee OA patients and 14 healthy controls were enrolled. A multiplex immunoassay was utilized for 10 cytokines in plasma and synovial fluid.
Results:
Plasma IL-2, IL-4, and IL-6 concentrations were significantly greater in knee OA patients than controls. Moreover, both plasma IL-4 and IL-6 were positively correlated with the radiographic severity of knee OA.
Conclusions:
Plasma IL-4 and IL-6 may serve as biomarkers reflecting the severity of OA.
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