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LDL Cholesterol Goal Attainment in Hypercholesterolemia: CEPHEUS Indonesian Survey

Muhammad Munawar1, Beny Hartono2, Sodiqur Rifqi3

  • 1Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia; ; Binawaluya Cardiac Center, Jakarta;

Acta Cardiologica Sinica
|April 29, 2016
PubMed

Insights

Indonesian patients with hypercholesterolemia often do not reach their LDL cholesterol goals despite lipid-lowering therapy. This highlights a significant gap in cardiovascular disease risk management for this population.

Area of Science:

  • Cardiology
  • Public Health
  • Pharmacology

Background:

  • Hypercholesterolemia management remains suboptimal, with many patients failing to achieve target cholesterol levels.
  • Lipid-lowering therapy effectiveness in Indonesian hypercholesterolemic patients requires further investigation.

Purpose of the Study:

  • To assess the achievement of lipid-lowering treatment goals in Indonesian patients with hypercholesterolemia.
  • To identify factors influencing goal attainment in this patient group.

Main Methods:

  • A survey of 979 hypercholesterolemic patients (≥18 years) on lipid-lowering treatment for ≥3 months was conducted.
  • Data collected included lipid concentrations, demographics, and clinical information, analyzed using 2004 NCEP-ATP III criteria.

Main Results:

  • Only 31.3% of Indonesian patients achieved their LDL cholesterol goals, significantly lower than the Asian average (49.1%).
  • Goal attainment was lowest (<12.1%) for patients targeting LDL-C <70 mg/dL and lower in those with metabolic syndrome (28%).
  • Achievement was inversely related to cardiovascular risk and baseline LDL-C; 65.1% of patients underestimated the impact of missed doses.

Conclusions:

  • A high percentage of Indonesian hypercholesterolemic patients on lipid-lowering drugs do not meet recommended LDL-C levels.
  • These patients remain at elevated risk for cardiovascular disease due to inadequate cholesterol management.
Abstract

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