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Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
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Association between Plasma Fibrinogen Level and Saphenous Vein Graft Patency

Sinan Cersit1, Serkan Cay1, Yavuzer Koza2

  • 1Department of Cardiology, Yuksek Ihtisas Heart-Education and Research Hospital, Ankara;

Acta Cardiologica Sinica
|April 29, 2016
PubMed

Insights

Elevated plasma fibrinogen levels are linked to blocked saphenous vein grafts after coronary artery bypass graft (CABG) surgery. Higher fibrinogen indicates a greater risk of graft occlusion, suggesting its role in atherosclerosis progression.

Area of Science:

  • Cardiovascular Science
  • Vascular Biology
  • Biochemistry

Background:

  • Fibrinogen plays a role in atherosclerosis pathogenesis.
  • Inflammation associated with atherosclerosis can elevate plasma fibrinogen.
  • Investigating fibrinogen's association with saphenous vein graft patency post-coronary artery bypass graft (CABG) surgery is crucial.

Purpose of the Study:

  • To determine if plasma fibrinogen levels are associated with the patency of saphenous vein grafts.
  • To evaluate the relationship between fibrinogen and graft status at least one year after CABG surgery.

Main Methods:

  • Study included patients with at least one saphenous vein graft at least 1 year post-CABG.
  • Patients underwent cardiac catheterization for anginal symptoms or positive stress tests.
  • Plasma fibrinogen levels were assessed via routine blood tests before coronary angiography.

Main Results:

  • Saphenous vein grafts were patent in 199 patients and occluded in 132.
  • Significantly higher plasma fibrinogen levels were observed in patients with occluded grafts (3.62 ± 0.82 g/L) compared to patent grafts (2.85 ± 0.49 g/L).
  • Logistic regression confirmed plasma fibrinogen levels as a significant predictor of vein graft patency (OR=0.27, p<0.001).

Conclusions:

  • Plasma fibrinogen levels are elevated in patients experiencing saphenous vein graft occlusion post-CABG.
  • Further research is needed to definitively establish the link between fibrinogen levels and saphenous vein graft patency.
Abstract

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