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Updated: Mar 22, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Plasma High-Sensitivity C-Reactive Protein Level is Associated with Impaired Estimated Glomerular Filtration Rate in
Hsu-Shien Shu1, Yi-Yun Tai2, Kai-Ting Chang3
1Department of Emergency Medicine;
Insights
High-sensitivity C-reactive protein (hsCRP) is linked to impaired kidney function in hypertensive patients. This study found hsCRP independently predicts reduced glomerular filtration rate (GFR) in individuals with hypertension.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Clinical Chemistry
Background:
- Inflammation and chronic kidney disease (CKD) are established risk factors for cardiovascular disease.
- The relationship between inflammatory biomarkers and impaired glomerular filtration rate (GFR) in hypertensive individuals remains incompletely understood.
- Hypertension is a major contributor to CKD and cardiovascular complications.
Purpose of the Study:
- To investigate the association between high-sensitivity C-reactive protein (hsCRP) levels and impaired GFR (IGFR) in patients with hypertension.
- To identify independent predictors of IGFR among hypertensive patients, including inflammatory markers.
Main Methods:
- Recruited 572 hypertensive patients from a tertiary medical center.
- Calculated GFR using the Modification of Diet in Renal Disease (MDRD) study equation; defined IGFR as GFR < 60 ml/min/1.73 m(2).
- Measured hsCRP levels using standardized kits and analyzed associations with GFR and IGFR using regression analyses.
Main Results:
- HsCRP levels showed a significant correlation with both GFR (p=0.01) and the presence of IGFR (p=0.009).
- Multivariate analysis identified hsCRP, age, and urinary albumin-to-creatinine ratio (UACR) as independent factors associated with GFR.
- HsCRP (OR=1.16), age (OR=1.09), and UACR (OR=1.02) independently predicted the presence of IGFR in hypertensive patients.
Conclusions:
- Elevated hsCRP levels are significantly associated with impaired GFR in hypertensive patients.
- HsCRP serves as an independent predictor of reduced kidney function in this population.
- These findings highlight the role of inflammation in the progression of kidney disease among hypertensives.
Background:
Both inflammation and chronic kidney disease (CKD) are related to cardiovascular disease. Whether inflammatory biomarkers are associated with impaired glomerular filtration rate (GFR) is unclear in hypertensives.
Methods:
We recruited hypertension patients from the cardiovascular clinic of a tertiary medical center in Taiwan. GFR was calculated using the 7-item Modification of Diet in Renal Disease (MDRD) study equation and impaired GFR (IGFR) was defined as GFR less than 60 ml/min/1.73 m(2). High-sensitivity C-reactive protein (hsCRP) kits were used for the measurement of the CRP levels.
Results:
In our study, 572 consecutive hypertensive patients were enrolled. The range of patient age was 26-91 years (mean 60.5 ± 11.7), and hsCRP and GFR ranged from 0.01 to 9.99 mg/L and 16.6 to 239.6 ml/min//1.73 m(2), respectively. HsCRP levels were correlated with GFR (p = 0.01) and the presence of IGFR (p = 0.009). Multivariate regression analysis showed hsCRP (p = 0.03), age (p < 0.001) and urinary albumin-to-creatinine ratio (UACR) (p = 0.002) are independent factors associated with GFR. Furthermore, hsCRP levels [odds ratio (OR) = 1.16, 95% CI = 1.03-1.31, p = 0.02], age (OR = 1.09, 95% CI = 1.07-1.12, p < 0.001), and UACR (OR = 1.02, 95% CI = 1.01-1.04, p < 0.001) independently predicted the presence of IGFR using binary logistic regression analysis.
Conclusions:
Information obtained from our study showed that hsCRP is associated with IGFR in hypertensives.
Key Words:
Chronic kidney disease; C-reactive protein; Glomerular filtration rate; Hypertension; Inflammation.
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