Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels
M Dambrova1, G Latkovskis2, J Kuka1
1Latvian Institute of Organic Synthesis, Riga, Latvia.
Summary
Trimethylamine N-oxide (TMAO) is linked to cardiovascular risk. This study found that diabetes, age, and BMI independently increase TMAO levels, suggesting TMAO
Area of Science:
- Cardiovascular Research
- Metabolic Disease Research
- Biomarker Discovery
Background:
- Systemic trimethylamine N-oxide (TMAO) is associated with atherosclerosis and cardiovascular risk.
- Plasma L-carnitine levels in individuals with high TMAO predict cardiovascular disease and adverse cardiac events.
- The relationship between TMAO, L-carnitine, and diabetes requires further investigation.
Purpose of the Study:
- To investigate the relationship between plasma TMAO and L-carnitine levels in the context of diabetes.
- To explore the independent associations of age, diabetes status, and body mass index (BMI) with TMAO levels.
Main Methods:
- Analysis of plasma samples from diabetic (db/db) and non-diabetic mice at 12 and 20 weeks of age.
- Assessment of body weight, insulin resistance, and TMAO concentrations in mice over an 8-week period.
- Multivariate linear regression analysis of TMAO levels in 191 patients undergoing percutaneous coronary intervention, considering age, diabetes status, BMI, and L-carnitine.
Main Results:
- Diabetic mice exhibited significantly higher TMAO and lower L-carnitine levels compared to non-diabetic controls.
- In patients, TMAO showed bivariate associations with age, total cholesterol, and L-carnitine.
- Multivariate analysis identified L-carnitine, age, diabetes status, and BMI as independent predictors of elevated TMAO levels.
Conclusions:
- Age, diabetes, and BMI are independently associated with higher TMAO levels, irrespective of L-carnitine.
- These findings support TMAO's role as a cardiovascular risk marker.
- Further research into TMAO's application in diabetes research is warranted.
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