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A SNARE and specific COPII requirements define ER-derived vesicles for the biogenesis of autophagosomes
1a Department of Genetics , University of Seville , Avda Reina Mercedes, Seville , Spain.
Abstract:
The endoplasmic reticulum (ER) is a major source for the generation of autophagosomes during macroautophagy. Our recent work in yeast shows that particular ER-derived vesicles are generated for the biogenesis of autophagosomes. These vesicles not only incorporate a SNARE protein that is largely ER-resident under nonstarving conditions, but also display COPII requirements for ER-exit that differ from conventional cargo-transporting vesicles. Our results suggest that specific intracellular traffic is launched at the ER for the transport of membranes to sites of autophagosome formation.
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