Related Experiment Video
Updated: Mar 22, 2026
Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
Published on: February 7, 2025
Membrane Induced Osteogenesis in the Management of Posttraumatic Bone Defects
Matheus L Azi1, Armando Augusto de A Teixeira, Ricardo B Cotias
1*Manoel Victorino Hospital, Secretary of Health for the State of Bahia, Bahia, Brazil;†AO Clinical Investigation and Documentation, Dübendorf, Switzerland; and‡Department of Biomechanics, Medicine and Rehabilitation of the Locomotor Apparatus, Ribeirao Preto Medical School, University of Sao Paulo (FMRP-USP), São Paulo, Brazil.
Objective:
To evaluate the union rate of posttraumatic bone defects treated with the induced membrane technique.
Design:
Single-center retrospective case series.
Setting:
Level I trauma center.
Patients/Participants:
Thirty-three patients who sustained 34 posttraumatic bone defects (19 tibia, 15 femur).
Intervention:
Staged management using the induced membrane technique described by Masquelet. After extensive debridement at the fracture site, a polymethylmethacrylate (PMMA) spacer was inserted into the resulting void. After soft tissue recovery, the spacer was removed, and the void, now enveloped by an induced membrane, was filled with an autologous iliac crest bone graft.
Main Outcome Measures:
Bone union rate, time to achieve bone union, length of hospital stay, number of surgeries, infection resolution, range of motion, musculoskeletal tumor society system functional score, and limb shortening.
Results:
The mean defect size was 6.7 cm, and infection was present in 23 (68%) of the bone defects. Bone union was evident in 91% of cases (31/34). The average time to union was 8.5 months. In 7 of 23 (30%) of infected cases, the infection recurred, and in 3 of them, the graft was resorbed, resulting in treatment failure.
Conclusion:
The induced membrane technique was effective for managing posttraumatic bone defects. A recurrence of infection was associated with treatment failure.
Level Of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
More Related Videos
11:20Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
Published on: March 29, 2018
09:35Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
Published on: September 11, 2015
Related Concept Videos
01:40Bone Remodeling
01:31Bone Remodeling and Repair
01:31Osteoclasts in Bone Remodeling
01:27Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
01:29Bone Formation by Intramembranous Ossification
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...