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PLATELET INDICES AND LIVER FIBROSIS EVALUATION IN CHRONIC HEPATITIS C

Irina Gîrleanu, Anca Trifan, Ana Maria Sîngeap

    Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
    |April 30, 2016
    PubMed

    Insights

    Platelet indices like mean platelet volume and platelet distribution width can indicate advanced liver fibrosis in chronic hepatitis C patients. These findings suggest their utility in assessing liver fibrosis severity non-invasively.

    Area of Science:

    • Hepatology
    • Hematology
    • Diagnostic Biomarkers

    Background:

    • Chronic hepatitis C is a significant cause of liver fibrosis.
    • Platelet indices have emerged as potential indicators of liver fibrosis severity.
    • Non-invasive methods for assessing liver fibrosis are crucial for patient management.

    Purpose of the Study:

    • To investigate the correlation between platelet indices and liver fibrosis stages.
    • To evaluate the diagnostic value of mean platelet volume (MPV), platelet large cell ratio (P-LCR), and platelet distribution width (PDW) in chronic hepatitis C.
    • To compare these indices with liver fibrosis assessment by transient elastography.

    Main Methods:

    • Prospective enrollment of 139 patients with chronic hepatitis C.
    • Simultaneous assessment of complete blood count parameters and liver fibrosis using transient elastography.
    • Statistical analysis comparing platelet indices (MPV, P-LCR, PDW) with fibrosis stages.

    Main Results:

    • Patients with advanced liver fibrosis showed significantly increased MPV (p < 0.002), P-LCR (P < 0.0001), and PDW (P = 0.003) compared to those with mild/moderate fibrosis.
    • A total of 139 patients were included, with 70.5% males and a mean age of 54.8 years.
    • The study utilized SPSS 17.0 for statistical analysis, with P < 0.05 considered significant.

    Conclusions:

    • Elevated platelet indices are associated with advanced liver fibrosis in chronic hepatitis C.
    • Platelet indices may serve as valuable non-invasive biomarkers for assessing liver fibrosis severity.
    • Transient elastography is a reliable method for staging liver fibrosis in conjunction with platelet indices.
    Abstract

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