Related Experiment Video
Updated: Mar 22, 2026

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
Published on: September 28, 2015
CORRELATIONS BETWEEN ARTERIAL HYPERTENSION INDUCED BY ANGIOTENSIN II AND SYSTEMIC INFLAMMATION IN RAT
Unlabelled:
Angiotensin II has articularly shown to play a key role in the regulation of inflammatory processes in hypertension.
Aim:
The present study aims to correlate the angiotensin II-induced hypertension 4th systemic inflammation.
Material And Methods:
We conducted an experimental study on Wistar male rats who received Ang II via subcutaneous miniosmotic pumps for 2 weeks. Rats were exposed to a 12h light /12h dark cycle. Sham rats were used as control. Systolic load pressure measurements and a flow cytometric analysis of lymphocyte surface markers were performed. After 14 days, the animals were euthanized under anesthesia with ylazine/ketaniine.
Results:
Systolic BP progressively and significantly increased in rats 4th Ang II chronic infusion. We observed a statistical significant difference (p = 0.00001), in terms of T lymphocytes percentage between control rats plasma and Ang H treated rats lasma, in 14 days.
Conclusions:
Angiotensin II is an important mediator of hypertension and directly promotes inflammation by noticeably increasing the quantity of T cells in kidney tissue.
Related Concept Videos
Hypertension II: Pathophysiology
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Drugs: Angiotensin II Receptor Blockers
Antihypertensive Drugs: Direct Renin Inhibitors
Hypertension and Regulation of Blood Pressure
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

