Related Experiment Video
Updated: Mar 22, 2026
14:19
Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
Published on: June 29, 2013
28.8K
INTRAUTERINE GROWTH RESTRICTION--PREDICTIVE SERUM MARKERS
Summary
Early screening for intrauterine growth restriction (IUGR) using pregnancy-associated plasma protein-A (PAPP-A) and mean platelet volume (MPV) can reduce neonatal complications. This first-trimester assessment enables timely intervention for at-risk pregnancies.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Neonatology
Background:
- Intrauterine growth restriction (IUGR) is a major cause of perinatal morbidity and mortality.
- Early identification of at-risk pregnancies is crucial for effective management.
- First-trimester assessment offers a window for proactive interventions.
Purpose of the Study:
- To identify serum and ultrasound markers in the first trimester for predicting IUGR.
- To improve perinatal outcomes in pregnancies complicated by IUGR.
- To establish early screening protocols for IUGR detection.
Main Methods:
- Prospective study involving pregnant women between 11 weeks and 0 days and 13 weeks and 6 days gestation.
- Measurement of serum pregnancy-associated plasma protein-A (PAPP-A).
- Assessment of mean platelet volume (MPV) and placental ultrasound appearance.
Main Results:
- First-trimester PAPP-A and MPV levels, alongside detailed history, can identify women at risk for IUGR.
- These markers facilitate early detection and targeted monitoring.
- The study suggests a potential for reducing neonatal complications through early screening.
Conclusions:
- Screening for IUGR in the first trimester using PAPP-A and MPV is feasible.
- Prophylactic treatment and protocol-based monitoring can be implemented for at-risk pregnancies.
- Early identification and management can significantly reduce neonatal morbidity and mortality associated with IUGR.
