INTRAUTERINE GROWTH RESTRICTION--PREDICTIVE SERUM MARKERS

Area of Science:

• Obstetrics and Gynecology
• Maternal-Fetal Medicine
• Neonatology

Background:

• Intrauterine growth restriction (IUGR) is a major cause of perinatal morbidity and mortality.
• Early identification of at-risk pregnancies is crucial for effective management.
• First-trimester assessment offers a window for proactive interventions.

Purpose of the Study:

• To identify serum and ultrasound markers in the first trimester for predicting IUGR.
• To improve perinatal outcomes in pregnancies complicated by IUGR.
• To establish early screening protocols for IUGR detection.

Main Methods:

• Prospective study involving pregnant women between 11 weeks and 0 days and 13 weeks and 6 days gestation.
• Measurement of serum pregnancy-associated plasma protein-A (PAPP-A).
• Assessment of mean platelet volume (MPV) and placental ultrasound appearance.

Main Results:

• First-trimester PAPP-A and MPV levels, alongside detailed history, can identify women at risk for IUGR.
• These markers facilitate early detection and targeted monitoring.
• The study suggests a potential for reducing neonatal complications through early screening.

Conclusions:

• Screening for IUGR in the first trimester using PAPP-A and MPV is feasible.
• Prophylactic treatment and protocol-based monitoring can be implemented for at-risk pregnancies.
• Early identification and management can significantly reduce neonatal morbidity and mortality associated with IUGR.