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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
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[Cardio-Ankle Vascular Index and Subclinical Peripheral Atherosclerosis in Patients With Stable Coronary Artery

A N Sumin, A V Osokina, A V Bezdenezhnykh

    Kardiologiia
    |April 30, 2016
    PubMed

    Insights

    Cardio-ankle vascular index (CAVI) indicates arterial stiffness, which is linked to noncoronary atherosclerosis in stable ischemic heart disease patients. Abnormal CAVI correlates with carotid artery issues but not lower extremity artery disease.

    Area of Science:

    • Cardiovascular Medicine
    • Vascular Biology
    • Atherosclerosis Research

    Background:

    • Stable ischemic heart disease (IHD) patients often exhibit subclinical atherosclerosis.
    • Assessing noncoronary atherosclerosis is crucial for comprehensive cardiovascular risk stratification.

    Purpose of the Study:

    • To investigate the association between cardio-ankle vascular index (CAVI) and subclinical noncoronary atherosclerosis.
    • To determine if CAVI can identify patients with advanced atherosclerosis in stable IHD.

    Main Methods:

    • A cohort of 511 stable IHD patients undergoing pre-operative assessment for aorto-coronary bypass surgery was studied.
    • Cardio-ankle vascular index (CAVI) was measured using the VaSera-1000 device.
    • Patients were categorized into normal (<9.0) and abnormal (≥9.0) CAVI groups.

    Main Results:

    • Patients with abnormal CAVI were older, more frequently female, and had higher rates of hypertension and multi-vessel coronary artery disease.
    • Abnormal CAVI was independently associated with increased intima-media thickness and carotid artery stenoses.
    • Elevated arterial stiffness (abnormal CAVI) was observed in 25% of patients and linked to carotid, but not lower extremity, arterial disease.

    Conclusions:

    • Cardio-ankle vascular index (CAVI) serves as a valuable indicator of arterial stiffness in stable IHD.
    • Abnormal CAVI is associated with subclinical noncoronary atherosclerosis, particularly in the carotid arteries.
    • CAVI may aid in identifying IHD patients with a higher burden of atherosclerosis, warranting further investigation.
    Abstract

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