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[The State of Coagulation Hemostasis and Fibrinolysis in Children With Essential Arterial Hypertension]

V V Dolgikh, M V Gomellya, E S Filippov

    Kardiologiia
    |April 30, 2016
    PubMed

    Insights

    Children with essential hypertension show higher risks of blood clots due to genetic factors and elevated levels of key blood clotting proteins, including fibrinogen and von Willebrand factor.

    Area of Science:

    • Pediatric Cardiology
    • Hematology
    • Vascular Biology

    Background:

    • Essential hypertension in children is a growing concern.
    • Thrombotic complications pose significant risks in pediatric hypertension.
    • Understanding the underlying hemostatic factors is crucial.

    Purpose of the Study:

    • To identify hemostatic markers associated with thrombotic risk in children with essential hypertension.
    • To investigate the relationship between familial thrombosis history and coagulation parameters.

    Main Methods:

    • Retrospective analysis of pediatric patients with essential hypertension.
    • Measurement of plasma levels of fibrinogen and soluble fibrin-monomer complexes.
    • Assay of von Willebrand factor activity and content.
    • Assessment of plasminogen activity.

    Main Results:

    • Children with essential hypertension and thrombotic risk exhibited a positive history of familial thrombosis.
    • Elevated levels of fibrinogen and soluble fibrin-monomer complexes were observed.
    • Increased activity and content of von Willebrand factor were noted.
    • Higher plasminogen activity was a characteristic finding.

    Conclusions:

    • Specific hemostatic abnormalities are linked to increased thrombotic risk in pediatric essential hypertension.
    • Familial thrombosis history may indicate a predisposition to these hemostatic changes.
    • These findings highlight potential targets for risk stratification and management.

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