[Predictive Value of Renal Dysfunction for Early and Long-Term Outcomes of Coronary Artery Bypass Grafting]

Area of Science:

• Cardiology
• Nephrology
• Surgical Outcomes

Background:

• Coronary artery bypass grafting (CABG) is a common procedure, but patient outcomes can be affected by renal function.
• Assessing the impact of renal dysfunction on prognosis after CABG is crucial for patient management.

Purpose of the Study:

• To evaluate the prognostic value of renal dysfunction for both immediate and long-term outcomes following coronary artery bypass grafting (CABG).

Main Methods:

• A cohort of 657 patients undergoing CABG was analyzed.
• Patients were categorized based on baseline glomerular filtration rate (GFR): GFR > 90 mL/1.73 m² (Group 1) and GFR 45-89 mL/1.73 m² (Group 2).
• Acute kidney injury (AKI) was diagnosed using AKI Network criteria.

Main Results:

• Perioperative AKI occurred in 23.6% of Group 1 and 41.55% of Group 2 patients, with significantly higher rates in Group 2 (p < 0.001).
• Patients with perioperative AKI experienced increased early cardiovascular complications and hospital mortality.
• During 12-month follow-up, 6.8% in Group 1 developed chronic kidney disease (CKD). In Group 2, CKD progression was noted in 14.7% with perioperative AKI versus 5.4% without (p > 0.05), and regression occurred in 45.1% with AKI versus 61.4% without (p = 0.004).
• 12 patients in Group 2 required hemodialysis, 10 of whom had perioperative AKI (p = 0.003).

Conclusions:

• The presence of pre-existing chronic kidney disease (CKD) and the development of perioperative AKI are associated with adverse cardiorenal prognoses after CABG.
• These findings highlight the importance of renal function assessment in patients undergoing CABG.