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Updated: Mar 22, 2026

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

Poly(lactic acid) nanofibrous scaffolds for tissue engineering.

Marco Santoro¹, Sarita R Shah², Jennifer L Walker²

¹Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005, United States.

Advanced Drug Delivery Reviews

|April 30, 2016

Summary

Poly(lactic acid) (PLA) nanofibers offer advanced scaffolds for tissue engineering and drug delivery. These biomimetic materials degrade into lactic acid, enabling applications in regenerative medicine across various organ systems.

Keywords:

Drug delivery Nanofibers PLA Scaffolds Tissue engineering

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Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Poly(lactic acid) (PLA) is a biocompatible and biodegradable synthetic polyester.
PLA nanofibers provide high surface area and mimic the extracellular matrix.
PLA's hydrolytic degradation into lactic acid suits medical applications.

Purpose of the Study:

To review recent advancements in PLA nanofibrous scaffolds for tissue engineering.
To explore the potential of PLA nanofibers in drug delivery systems.
To discuss future perspectives for PLA nanofibrous scaffolds in regenerative medicine.

Main Methods:

Review of literature on PLA nanofiber fabrication and applications.
Analysis of PLA scaffold properties for tissue regeneration.
Evaluation of drug release kinetics from PLA nanofiber carriers.

Main Results:

PLA nanofibers enhance musculoskeletal, nervous, cardiovascular, and cutaneous tissue engineering.
Nanofibrous PLA scaffolds show promise for controlled drug delivery.
Fabrication parameters significantly influence drug release profiles.

Conclusions:

PLA nanofibrous scaffolds are versatile for diverse tissue engineering applications.
Further research can optimize PLA nanofibers for enhanced regenerative and therapeutic outcomes.
PLA nanofibers represent a promising platform for future medical innovations.