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Related Experiment Video

Updated: Mar 22, 2026

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Inflammation modulates LC3 expression in human preterm delivery.

Laura Avagliano1, Valentina Massa1, Sara Zullino2

  • 1a Department of Health Sciences , San Paolo Hospital Medical School, University of Milan , Milan , Italy and.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|April 30, 2016
PubMed
Summary

Autophagy marker LC3 expression in the placenta varies with inflammation. Reduced LC3 in preterm delivery with inflammation suggests a link between autophagy and placental inflammatory status.

Keywords:
Autophagychorioamniotic membranesplacentapreterm birth

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Area of Science:

  • Cellular Biology
  • Reproductive Medicine
  • Pathology

Background:

  • Autophagy is a cellular process crucial for responding to stress like inflammation and hypoxia.
  • Understanding autophagy in placental development is vital for pregnancy outcomes.

Purpose of the Study:

  • To investigate autophagy expression, specifically the LC3 marker, in human placentas from preterm deliveries.
  • To correlate autophagy levels with the presence and severity of placental inflammatory lesions.

Main Methods:

  • Analyzed 25 preterm placentas (before 34 weeks gestation) using immunohistochemistry, immunofluorescence, and qPCR.
  • Assessed LC3 expression in relation to histological classification of preterm delivery, distinguishing between cases with and without inflammatory lesions.
  • Examined LC3 localization in inflammatory cells and trophoblastic cells of the chorion laeve.

Main Results:

  • LC3 expression was detected in placentas both with and without inflammation.
  • Strong LC3 immunoreactivity was found in neutrophils within inflammatory infiltrates.
  • Trophoblastic cells in the chorion laeve showed reduced LC3 expression in preterm deliveries with inflammation compared to those without.
  • Decreased LC3 staining correlated with increased severity of fetal inflammatory response signs.

Conclusions:

  • Placental LC3 expression is influenced by histological features, particularly inflammation.
  • Autophagy levels in the placenta may have clinical relevance in the context of inflammatory conditions.
  • Findings suggest a relationship between autophagy and the inflammatory status in preterm delivery.