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Ciprofloxacin for methicillin-resistant Staphylococcus aureus infections
E A Piercy1, D Barbaro, J P Luby
1Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas 75235.
Antimicrobial Agents and Chemotherapy
|January 1, 1989
Summary
Oral ciprofloxacin effectively treated methicillin-resistant Staphylococcus aureus infections in most patients. However, resistance developed in some cases, highlighting the need for careful monitoring during treatment.
Area of Science:
- Infectious Diseases
- Pharmacology
- Microbiology
Background:
- Methicillin-resistant Staphylococcus aureus (MRSA) presents a significant public health challenge due to its resistance to common antibiotics.
- Effective treatment options for MRSA infections and colonization are crucial to reduce morbidity and mortality.
Purpose of the Study:
- To evaluate the efficacy and safety of oral ciprofloxacin in treating patients with MRSA infections and/or colonization.
- To assess the rates of clinical and bacteriologic cure, suppression of colonization, and emergence of ciprofloxacin resistance.
Main Methods:
- A cohort of 37 patients with confirmed MRSA infections and/or colonization received oral ciprofloxacin at a dosage of 750 mg twice daily.
- Outcomes including clinical cure/improvement, bacteriologic cure, suppression of MRSA colonization, and development of ciprofloxacin resistance were monitored.
Main Results:
- A high rate of clinical cure or improvement (91%) was observed in patients treated with ciprofloxacin.
- Bacteriologic cure was achieved in 60% of patients, and MRSA colonization was suppressed in 55%.
- Emergence of ciprofloxacin-resistant strains was noted in 6 out of 37 patients (16.2%).
Conclusions:
- Oral ciprofloxacin demonstrates significant clinical efficacy in treating MRSA infections and reducing colonization.
- The emergence of ciprofloxacin resistance in a notable proportion of patients necessitates careful consideration and monitoring during therapy.
- Further research may be warranted to optimize treatment strategies and mitigate resistance development.