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Pegylated interferon therapy during early pregnancy for hepatitis B infection: does it prevent vertical transmission?
Halil Ibrahim Atasoy1, Pinar Sirmatel2, Fatma Sirmatel3
1a Department of Paediatrics , Faculty of Medicine, Abant Izzet Baysal University , Bolu , Turkey.
Abstract:
In general, interferon (IFN) is avoided during pregnancy due to the possibility of fetal side effects. We, herein, reported two child-bearing women with chronic hepatitis B (HB) infection who used pegylated interferon alfa 2b (PEG IFNα 2b) in first trimester unintentionally. We compared HB contracting rates of gestations in which IFN was used and not used. The cases are unique in that they could highlight the importance of IFN use in early gestation for preventing vertical transmission particularly if combined with antiviral therapy for the rest of pregnancy.
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