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Updated: Mar 22, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
Cross-species comparisons of host genetic associations with the microbiome
Julia K Goodrich1, Emily R Davenport1, Jillian L Waters2
1Department of Molecular Biology and Genetics, Cornell University, Ithaca NY, USA.
Abstract:
Recent studies in human populations and mouse models reveal notable congruences in gut microbial taxa whose abundances are partly regulated by host genotype. Host genes associating with these taxa are related to diet sensing, metabolism, and immunity. These broad patterns are further validated in similar studies of nonmammalian microbiomes. The next generation of genome-wide association studies will expand the size of the data sets and refine the microbial phenotypes to fully capture these intriguing signatures of host-microbiome coevolution.
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