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Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
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Deciphering intratumor heterogeneity using cancer genome analysis.
Daeun Ryu1,2, Je-Gun Joung1, Nayoung K D Kim1
1Samsung Genome Institute, Samsung Medical Center, Seoul, Korea.
Human Genetics
|April 30, 2016
Summary
Intratumor heterogeneity, the presence of diverse cancer cell populations within a tumor, impacts treatment effectiveness. Understanding tumor subclones is key to developing precise cancer therapies.
Area of Science:
- Oncology
- Genomics
- Molecular Biology
Background:
- Intratumor heterogeneity drives diverse cancer phenotypes and affects therapeutic outcomes.
- Drug-resistant tumor subclones can be present at low frequencies or emerge through acquired mutations.
Purpose of the Study:
- To review current approaches for understanding intratumor heterogeneity.
- To highlight the clinical value of monitoring tumor subclonal architecture.
Main Methods:
- Clonal analysis using whole exome or genome sequencing.
- Multiregional biopsies for molecular characterization.
- Deep sequencing for low allele fraction variants.
- Single-cell sequencing for comprehensive subclone identification.
Main Results:
- Various sequencing and biopsy techniques allow for the detection and monitoring of tumor subclones.
- These methods enable the measurement of low-frequency variants and the identification of minor cell populations.
Conclusions:
- Understanding intratumor heterogeneity and subclonal architecture is crucial for advancing precision cancer medicine.
- Monitoring subclonal populations can inform the development of more effective cancer therapeutic strategies.
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