Related Experiment Video
Updated: Mar 22, 2026
05:18
Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
Published on: May 26, 2023
2.0K
What we have learned about antenatal corticosteroid regimens
Ronald J Wapner1, Cynthia Gyamfi-Bannerman1, Elizabeth A Thom2
1Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY 10032.
Seminars in Perinatology
|April 30, 2016
Summary
Antenatal corticosteroids are standard care for preterm birth risk. Research continues to explore optimal dosing and expanded gestational age criteria for steroid use in high-risk pregnancies.
Area of Science:
- Obstetrics and Gynecology
- Neonatal Medicine
- Pharmacology
Background:
- Antenatal corticosteroids (ACS) are a cornerstone of preterm birth management.
- Established benefits exist for women between 24-34 weeks gestation.
- Uncertainties remain regarding optimal dosing and use outside this gestational range.
Purpose of the Study:
- To address key questions surrounding antenatal corticosteroid administration.
- To investigate optimal dosing frequency for ACS.
- To evaluate the potential expansion of gestational age criteria for ACS.
Main Methods:
- Clinical trials and observational studies.
- Analysis of data from the Maternal-Fetal Medicine Units (MFMU) Network.
- Focus on women at risk for preterm delivery.
Main Results:
- Confirmed benefits of ACS in the 24-34 week gestation window.
- Ongoing research by the MFMU Network addresses dosing and extended gestational age.
Conclusions:
- Antenatal corticosteroids are vital for preterm birth prevention.
- Further research is needed to refine ACS protocols.
- The MFMU Network is instrumental in advancing ACS evidence-based practice.
Related Concept Videos
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
1.9K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.9K
01:26COPD: Management Using Bronchodilators and Corticosteroids
1.1K
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
1.1K
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
606
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
606
01:28Dosage Regimens: Designs and Approaches
449
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
449
01:15Drug Dosage Regimen: Overview
4.6K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
4.6K
01:24Dosage Regimen: Individualization
276
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
276