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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
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Thyroid metastasis of bladder transitional cell carcinoma.
S M M Mirjalili1, S Hashemipour, S Salehi
1Buali hospital, Buali St., Qazvin, Iran, 3413786165. am.kazemifar@yahoo.com.
The Malaysian Journal of Pathology
|April 30, 2016
Summary
Thyroid cancer metastasis is rare. This case study details a patient whose bladder transitional cell carcinoma (TCC) metastasized to the thyroid gland, confirmed by immunohistochemistry.
Area of Science:
- Oncology
- Pathology
- Endocrinology
Background:
- Thyroid gland metastasis is an uncommon clinical presentation.
- Transitional cell carcinoma (TCC) of the bladder is a significant malignancy.
- Follicular adenoma is a common benign thyroid neoplasm.
Observation:
- A 75-year-old male presented with hematuria and bone pain.
- History of partial thyroidectomy for follicular adenoma and subsequent poorly-differentiated thyroid carcinoma.
- Resection of a bladder tumor revealed malignant histology with a specific immunohistochemical profile (CK7+/CK20+/34 Beta E12+/CEA-/PSA-).
Findings:
- Re-examination of thyroid sections confirmed metastatic disease.
- Immunohistochemical analysis of thyroid tumor cells showed CK7+/CK20+/34 Beta E12+/CEA-/TTF1-.
- The immunohistochemical profile strongly supported metastasis of bladder TCC to the thyroid gland.
Implications:
- This case highlights the importance of considering rare metastatic sites in cancer diagnosis.
- Immunohistochemistry is crucial for differentiating primary thyroid tumors from metastases.
- Understanding metastatic patterns can inform clinical management and prognosis.
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